The in vivo gut micronucleus test detects clastogens and aneugens given by gavage
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چکیده
منابع مشابه
Chromosomal aberrations, clastogens vs aneugens.
Current anticancer therapy may be one of the most important exogenous sources of exposure to genotoxic agents in US, Japan, and Europe, where approximately 40-55 percent of the population is diagnosed with cancer at a certain point in their life. This review focuses on recent efforts to integrate a novel biomarker, gamma-H2AX, into anticancer drug screening to classify the mode of action (MoA) ...
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The marine environment receives a wide variety of chemical inputs, many of which have the potential to damage DNA or interfere with the process of cell division. Here we describe a new assay based on the early embryo and larval stages of a planktonic spawning, tube dwelling marine worm, Pomatoceros lamarckii, which for experimental purposes has the advantage of producing large numbers of ripe g...
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15 صفحه اولThe micronucleus test as an in vivo cytogenetic method.
Methods are currently being explored which would permit the application of cytogenetic procedures such as metaphase and anaphase analyses to in vivo mammalian systems in order that due consideration may be given to metabolic activation or detoxification reactions which might affect the mutagenic or clastogenic (chromosome breaking) potential of environmental agents under study. It has been reco...
متن کاملPotential thresholds for genotoxic effects by micronucleus scoring.
The concept of thresholds in genotoxicity has been open for debate in the last decades. The micronucleus (MN) test contributed to a large extent in understanding the dose-response relationship for aneugens and clastogens. The threshold concept for aneuploidy is well accepted by the scientific community based on the data and for mechanistic reasons. The concept of threshold for clastogens is sti...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2001
ISSN: 1464-3804
DOI: 10.1093/mutage/16.1.39